Host Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing

Our understanding of how the host immune system thwarts bacterial Outdoor Ottoman evasive mechanisms remains incomplete.Here, we show that host protease neutrophil elastase acts on Acinetobacter baumannii and Pseudomonas aeruginosa to destroy factors that prevent serum-associated, complement-directed killing.The protease activity also enhances bacterial susceptibility to antibiotics in sera.These findings implicate a new paradigm where host protease activity on bacteria acts Dog Collar Battery combinatorially with the host complement system and antibiotics to defeat bacterial pathogens.